Wachters' Weekly Special: June 16 to 22, 2012 Heart Healthy Month
#20 Co Enzyme Q-10
Heart Disease and Coenzyme Q10:
Coenzyme Q-10 protects the heart during periods of lack of oxygen (ischemia), when narrowing or blocking of the coronary arteries occurs. Other medical procedures where Coenzyme Q10 can help are open heart surgery, coronary bypass and angioplasty where ischemia is prevalent. Angina, heart failure and sudden death could also be assisted with Coenzyme Q10.
Pre-treatment with Coenzyme Q10 also minimizes myocardial injury caused by heart bypass surgery and the Coenzyme Q10 actually improves heart function.
Regular doses of Coenzyme Q10 is known to reduce the frequency of anginal attacks and Coenzyme Q10 can improve physical activity in angina patients.
Patients with Coronary Disease should not decrease a Coenzyme Q10 regimen suddenly as severe heart problems could develop.
Coenzyme Q10 improves the heart's ability to survive in limited oxygen situations (Hypoxia) e.g. high altitudes, clogged arteries, angina.
support for CoQ10's benefits for heart health
By Stephen Daniells
“This study adds significantly to a growing body of evidence that CoQ10 supplementation may be an efficacious complementary method for improving cardiac function in heart failure patients,” said Kevin Connolly, director of scientific affairs and product development.
The majority of research looking at the benefits of CoQ10 for health has focused on the cardiovascular diseases. The heart tissue contains the highest concentration of CoQ10 in the human body (about 132 nanomoles per gram), and there is evidence, said the researchers of the new study, that plasma CoQ10 levels decrease in patients with advanced chronic heart failure (CHF).
According to the Study on Heart failure Awareness and Perception in Europe (SHAPE), about 14m people in Europe suffer from chronic heart failure (CHF) with the number forecast to rise to 30 m by 2020. About 5m people suffer from the condition in the US.
To test if supplementation of the coenzyme could improve cardiocirculatory efficiency and endothelial function in patients with CHF, Romualdo Belardinelli from the Lancisi Heart Institute, Italy and her colleagues recruited 23 patients (20 men, average age 59) with stable CHF for a double-blind, placebo-controlled cross-over study.
Participants were randomly assigned to one of four four-week intervention groups: oral supplements of CoQ10 CoQ10 plus supervised exercise training (ET) five times a week; placebo; or placebo plus ET.
The results, published on-line ahead of print in the European Heart Journal (doi:10.1093/eurheartj/ehl158), show that the heart's functional capacity improved significantly by nine per cent, as measured by the peak volume of oxygen consumed (VO2), for the CoQ10 compared to placebo. Similar results were observed for the CoQ10 plus exercise groups.
Blood flow also increased, as measured by endothelium-dependent dilation of the brachial artery (EDDBA) by 38 per cent after CoQ10 supplementation.
Supplementation with CoQ10 tripled plasma CoQ10 levels, and CoQ10 plus exercise further increased levels.
This result is important, said Connolly, because the formulation of CoQ10 is reported to play a key role in its bioavailability. Since the coenzyme is lipophilic (fat-loving) its absorption is enhanced in the presence of fats.
The coenzyme is concentrated in the mitochondria - the 'power plants' of the cell - and plays a vital role in the production of chemical energy by participating in the production of adenosince triphosphate (ATP), the body's co-called 'energy currency'.
A role beyond the mitochondria is also acknowledged, with CoQ10 acting as a potent antioxidant, and it is this role that is proposed to be behind the benefits observed in this study, by reducing reactive oxygen species (ROS) levels, which results in increased levels of nitric oxide and widening of the blood vessels (vasodilation).
“Oral CoQ10 improves functional capacity, endothelial function, and left ventricle contractility in CHF without any side effects,” concluded Belardinelli.
the majority of research has focussed on the role of CoQ10 in
cardiovascular health, the sphere of study is widening with studies
emerging linking supplements of coenzyme to benefits for diabetes,
cancer (breast, lung and prostate), male infertility, and kidney
WH Heart N More:
Historical use of herbs:
Garlic Historical usage:
Numerous trials have looked at the role of garlic supplements in heart disease. Many of these randomized studies showed positive benefits of garlic in heart disease: lowering total cholesterol, LDL cholesterol (the Bad cholesterol) and triglycerides A few small randomized trials also suggested the benefits of garlic in the prevention of platelet aggregation and thrombosis (the formation of plaques in the blood). Another study also showed that aged garlic extracts lowered blood pressure.
Hawthorne Berries Historical use: Hawthorne berry today is most associated with its widespread use as a tonic for the heart. Specifically, it protects arterial walls, has the ability to dilate (enlarge) coronary blood vessels (the vessels supplying the heart with vital oxygen, blood, and nutrients), and strengthen the heart's pumping ability. Because of these powerful cardiac benefits, it is now one of the most prescribed heart remedies in Europe.
Those people who suffer from angina, therefore, would most likely benefit by hawthorne berry's ability to increase blood flow through the arteries. Additionally, for the same reason, those afflicted with hypertension (high blood pressure) may alleviate their condition since narrowed arteries require the heart to work more strenuously in getting blood through them.
People who suffer from tachycardia (rapid heart beating) and cardiac arrhythmia (irregular heart beating) may also find relief. It also has antioxidant properities which may help offset arterial damage from plaque formation and accumulation.
In short, hawthorne berry is seen by some as an all-purpose heart medicine.
Astragalus Historical usage:
Astragalus is a native plant to areas of Northern China and Mongolia and has over 2,000 varieties. Traditional Chinese medicine has used this herb because it possesses the ability to enhance the immune system and stimulate forces of chi (life forces), which might include energy and peace.
Claimed Health Benefits
Boosts immune system
Protects against cancer
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Hawthorn berries are widely used to strengthen and balance the heart and circulatory system. Researchers believe that hawthorn helps the heart in several ways. It dilates coronary arteries to improve blood supply. It may increase the heart's pumping force, eliminate heart rhythm irregularities and remove cholesterol from arterial walls. It has been used to reduce angina attacks (with long term use) and prevent cardiac complications in elderly patients with pneumonia and influenza.
Chinese Kudzu has been used in China since at least 200 BC to reduce the abuse of alcohol. In 1993, scientists at Harvard discovered that daidzin, an active ingredient, helped golden Syrian hamsters reduce their preference for alcohol over water. Chinese Kudzu contains daidzein, which blocks alcohol metabolism in the liver.
Grapeseed extract is one of nature's most potent antioxidants. It has been used to treat deteriorating diseases and conditions with great success. Grape Seed extract helps Vitamin C enter the body's cells, thus strengthening the cell membranes, and protecting the cells from oxidative damage.
L-Arginine is needed by the body to synthesize nitric acid. Nitric acid oxide helps arterial walls relax, which allows blood to flow more readily throughout the body. This, in turn, can lead to such benefits as stroke prevention, increased athletic performance, mitigating hypertension, improving erections, lowering blood pressure, and decreasing risk of heart attacks.
L-Arginine is also a powerful HGH (human growth hormone) releaser, burning fat, enhancing the immune system, and helping to build muscle. The pituitary gland at the base of the brain is responsible for producing human growth hormone, but precursors such as L-Arginine can help stimulate this gland to produce more of it. In addition, a substance called Somatostatin can inhibit the production and release of HGH by the pituitary gland; L-Arginine appears to block these undesirable effects.
Another promising benefit of L-Arginine is evidence that it can significantly enhance anti-cancer defenses. It has also been shown to accelerate the healing of acid induced gastric ulcers, and has had positive effects on patients with chronic persistent hepatitis.
L-Cystine is the stable, oxidized form of L-Cysteine. Cystine is known as a disulfide amino acid because it consists of two Cysteine segments with their respective sulfur atoms bonded firmly together. The body can convert L-Cysteine to L-Cystine and vice versa, however L-Cysteine is the more bio-active of the two. An adequate supply of Vitamins C and B6 should always accompany any Cysteine or Cystine supplementation. Amino acid, antioxidant, and chelating agent. Synthesized from L-Methionine. Protects cells from radiation, free radicals, pollution and is claimed to be a chelator for lead and other toxins. Has high sulfur content. Cysteine is also a part of the reduced glutathione molecule, which plays an important role in the liver’s detoxification pathways. Glutathione binds and conjugates toxins, promoting their excretion.
It is directly depleted by cigarette smoking, the depletion of which may be partially related to the faster aging of skin in smokers. L-Cysteine is a sulfur containing amino acid which, together with glycine & glutamic acid, forms the all-important antioxidant glutathione. L-Cysteine contributes to the formation of protein in our bodies. It plays a role in energy metabolism, both by being able to convert to glucose & be used as fuel, & by playing a part in the synthesis of fatty acids. It acts in the liver to help detoxify carcinogens & other dangerous chemicals. Cysteine is essential for T-cell proliferation & activation in your immune system. Cysteine is a major component of skin, hair, & fingernails. Studies show that cysteine supplementation can increase hair shaft diameter and hair growth density in some cases of hair loss.
The benefits and functions attributed to oral ingestion of L-cystine include:
• Help with skin health.
• Stop hair loss & aid hair growth.
• Aid wound healing from injuries, burns, or surgery.
• Help protect us from the adverse effects of alcohol consumption, cigarette smoking, & other chemicals.
• Support the liver when there are liver disorders.
• Enhance absorption of iron.
• Ameliorate chemical sensitivity reactions.
• Promote the production of red & white blood cells.
• Support cartilage
Methionine is one of the essential sulfur amino acids. As a "methyl donor", methionine contributes to the formation of numerous important compounds in the body. This process, methylation, is implicated in depression. Methionine functions as a sulfur donor to aid in your body's detoxification processes. It can convert to other sulfur amino acids, to glutathione, and is a precursor to S-adenosyl methionine. Sunflower seeds are a good source of methionine. Diets deficient in methionine may result in destructive breakdown and metabolism of protein. Methionine is required for the synthesis of cysteine and carnitine.
Methionine plays a key role in regulating the availability of folic acid. Methionine deficiency makes folic acid unusable and may induce a build up of the unusable folic acid. There is a tendency for allergic (high histamine) persons to be methionine deficient. They may respond favorably to methionine, because it lowers blood histamine levels.
It is a good source of sulfur, it is important for the breakdown of fat in liver and arteries. As a digestive aid it helps detoxify harmful agents, aids muscle weakness, prevents brittle hair, is beneficial for allergic chemical sensitivities and osteoporosis.
benefits and functions attributed to oral ingestion of L-methionine
• Allergies & asthma.
• Helps lower copper with copper toxicity.
• Beneficial against the toxic effects of radiation.
• Improves healing from surgery & other wounds.
• Useful for the high histamine type of schizophrenia - is most useful in those schizophrenics who are depressed.
• Liver disorders.
• Withdrawal symptoms and depression from heroin, barbiturate, or amphetamine reduction.
• As an adjunct to L-dopa treatment for Parkinson's disease.
• Antioxidant therapy.
Thiamin (vitamin B1) Prevents beri-beri, keeps nerves healthy, stimulates appetite and good digestion and promotes growth. Deficiency results in poor appetite, nervousness, constipation, fatigue, weakness, retarded growth, and beri-beri in severe deficiency.
Riboflavin (vitamin B2) Keeps eyes and skin healthy, aids in normal functioning of nervous system and promotes growth. Deficiency results in sores in angles of mouth and fold of nose; sore, swollen and chapped lips; swollen, fissured and painful tongue, itching and burning sensation in the eyes; and retarded growth.
Niacin (vitamin B3) Promotes growth and normal digestion and keeps nerves and skin healthy.
Lack of niacin results in red skin that becomes pigmented; sore mouth, tongue and throat; digestive and nervous disturbances; loss of appetite and weight; and pellagra in severe deficiency (cracked skin, nervous disorder and diarrhea)
Pyridoxine (vitamin B6) Helps the body use carbohydrates, fats and proteins, is essential in converting tryptophan (essential amino acid) to niacin and linoleic acid (fatty acid) to arachidonic acid (fatty acid in animal fat).
Lack of pyridoxine results in appetite loss, nausea and vomiting; nervous irritability and convulsions; and dermatitis around the eyes, mouth, nose and behind the ears.
Folic Acid (Folate) Helps cure megaloblastic anemia; is important in DNA synthesis that controls cell function, heredity and tissue growth; and regenerates red blood cells.
Deficiency results in macrocytic anemia (disturbed red blood cell development), glossitis (symptoms of riboflavin deficiency), diarrhea, and malabsorption.
Cobalamin (vitamin B12) Helps cure pernicious anemia (failure to absorb cobalamin); involved in metabolism of carbohydrates, proteins, fats, nucleic and folic acid, and normal cell function; and is essential in red blood cell maturation.
Cobalamin deficiency leads to pernicious anemia, changes in the nervous system and retarded growth. .
. Zinc Helps the body use protein and carbohydrates; is vital for growth and development; synthesis of cell protein (DNA & RNA formation); and proper functioning of immune system. Lack of zinc results in growth failure, impaired wound healing, impaired sense of taste and smell.
Aids regulation of body processes like normal heart rhythm and in normal functioning of body enzymes. Deficiency leads to irritability, abnormal heart rhythm, emotional tension, depression, and muscular weakness.
Selenium Part of certain enzymes that act as antioxidants which help fight cell damage; helps prevent particular type of protein-calorie malnutrition; enhances proper immune response; and aids proper functioning of heart muscle.
Vitamin D aids in the absorption of calcium form the intestinal tract and the breakdown and assimilation of phosphorus, which is required for bone formation.
The scientific literature has confirmed vitamin C's key role in:
Immune system function,
Collagen repair and formation,
Antioxidant protection and function
Detoxification, and more.
beneficial in the prevention and treatment of osteoporosis
lowers cholesterol and helps prevent cardiovascular disease
aids the nervous system, especially in impulse transmission
may prevent colorectal cancer
keeps the heart beating regularly
relieves cramps in legs
helps metabolize the body's iron
Vitamin A prevents night blindness and other eye problems, as well as some skin disorders such as acne. It enhances immunity, may heal gastrointestinal ulcers, protects against pollution and cancer formation and is needed for the maintenance and repair of epithelial tissues.
Vitamin E is a powerful antioxidant that is important in the prevention of cancer and cardiovascular disease. It improves circulation, is necessary for tissue repair and is useful in treating premenstrual syndrome and fibrocystic disease of the breast. It promotes normal blood clotting and healing, reduces scarring from some wounds, reduces blood pressure and aid in preventing cataracts. It also is key in promoting healthy muscles and nerves as well as healthy skin and hair.
Pantothenic acid is used throughout the body. It is required for glandular balance and production of hormones and enzymes. Thus, it affects energy levels, growth and tissue repair and our ability to deal well with all types of stress. Deficiency can cause chronic fatigue, hair loss and graying, muscular weakness, digestive disorders, constipation, depression and many other debilitating symptoms. Deficiency can also be a factor in allergies and asthma.
Biotin assists in the metabolism of fat and protein. It nourishes muscles.
Garlic is one of the most important herbs; it has a broad range of well-documented healing properties; antimicrobial against bacteria, fungi and worms, fights blood clots, stimulates bile, lowers blood sugar and cholesterol, improves blood LDL/HDL ratio. Garlic has been found to be effective in treating a myriad of conditions in the circulatory, urinary, respiratory and digestive systems largely because of its aromatic sulfur-containing oils.